Transcriptomic analysis of spleens from mice subjected to chronic low-dose radiation hindlimb unloading or a combination of both

The purpose of this study was to evaluate transcriptional changes in mouse spleens using a ground-based model for spaceflight. This model includes prolonged unloading and low-dose irradiation. Low-dose-rate gamma-radiation was delivered to 6-month old female C57BL/6J mice using 57Co plates (0.04 Gy) to simulate the radiation environment of spaceflight. Anti-orthostatic tail suspension was used to model the unloading fluid shift and physiological stress aspects of the microgravity component of spaceflight. Mice were hindlimb suspended and/or irradiated for 21 days. Mice were euthanized and spleens collected 7 days following treatment. RNA sequencing data was generated to assess transcriptional changes in these spleens.

Data and Resources

Additional Info

Field Value
Maintainer GeneLab Outreach
Last Updated April 23, 2025, 23:06 (UTC)
Created April 1, 2025, 03:06 (UTC)
accessLevel public
accrualPeriodicity irregular
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harvest_source_title DNG Legacy Data
identifier nasa_genelab_GLDS-211_ye6w-xar9
issued 2021-05-21
landingPage https://data.nasa.gov/dataset/transcriptomic-analysis-of-spleens-from-mice-subjected-to-chronic-low-dose-radiation-hindl
license http://www.usa.gov/publicdomain/label/1.0/
modified 2023-01-26
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