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Modeling cellular responses to serum and vitamin D in microgravity using a...
The microgravity environment aboard the International Space Station (ISS) provides a unique stressor that can help understand underlying cellular and molecular drivers of... -
Microbial Observatory (ISS-MO): Antimicrobial resistance genes
The environmental samples were collected with the polyester wipes from eight different locations in the International Space Station (ISS) during two consecutive sampling... -
Microbial Observatory (ISS-MO): Study of BSL-2 bacterial isolates from the...
In an on-going Microbial Observatory experimental investigation on the International Space Station (ISS) multiple bacterial isolates of Biosafety Level 2 (BSL-2) were isolated... -
Microbial Observatory (ISS-MO): Molecular characterization of Bacillus...
As part of an ongoing effort to catalogue microbial communities inhabiting the International Space Station (ISS) crew-associated environmental samples were collected from the... -
Approaches for Surveying Cosmic Radiation Damage in Large Populations of...
The Cosmic Ray Exposure Sequencing Science (CRESS) payload system is a proof of concept experiment to assess the genomic impact of space radiation on seeds. CRESS was designed... -
The response of murine cartilages to 30 days of microgravity
Articular and sterno-costal cartilages were isolated from skeletally-mature mice flown for 30 days on the BION-M1 mission. Samples were characterized histologically for... -
Osteocytes transcriptome is altered during spaceflight
Bone loss is one of the major health problems for astronauts during long-term spaceflight and for patients during prolonged bed rest or paralysis. Growing evidence suggests that... -
Genome sequencing of Staphylococcus, Burkholderia, and Ralstonia bacterial...
This repository holds genome assemblies for Staphylococcus, Burkholderia, and Ralstonia bacterial isolates isolated from the ISS between the years of 2006-2015. Information on... -
small-RNA sequencing of sEV isolated from plasma of astronauts
We sought to determine whether the spaceflight environment can induce alterations in small extracellular vesicles (sEV) smallRNA content and their utility as biomarkers. Using... -
New insights into the role of lncRNA after spaceflight
We analyzed the transcriptional profile by RNA-sequencing of exosomal content isolated from blood plasma of three astronauts who flew on various ISS missions between 1998-2001.... -
Draft genome sequence of Klebsiella quasipneumoniae subsp. similipneumoniae...
In 2015, the Advanced Resistive Exercise Device (ARED) foot panel on the International Space Station (ISS) was sampled to identify culturable microorganisms. The whole-genome of... -
Fungal Diversity associated with space-craft assembly facility (SAF)
Draft genome sequences of Fungi isolated from Mars 2020 Spacecraft assembly facility are reported. The fungal strains were isolated from samples collected from cleanroom... -
Draft Genome Sequences of novel Agrobacterium genomospecies 3 Associated...
The whole-genome sequences (WGS) of three pathogenic bacterial strains collected from the International Space Station (ISS) were generated and identified as being part of Class... -
Diagnosing an Opportunistic Fungal Pathogen on Spaceflight-Grown Plants...
Sustainable agriculture in microgravity is integral to future long-term space exploration. To ensure the efficient and sustainable cultivation of plants in space, a contingency... -
Effects of Spaceflight on Bone Microarchitecture in the Axial and...
This study investigated the effects of a 14-day spaceflight on bone mass, density and microarchitecture in weight bearing (femur and humerus) and non-weight bearing (2nd) lumbar... -
Characterization of mouse ocular responses (intraocular pressure) to a...
The health risks associated with spaceflight-induced ocular structural and functional damage has become a recent concern for NASA. The goal of the present study was to... -
Transcriptional profiling of roots and shoots from Brachypodium distachyon...
Most major cereal grain crops are monocots. Yet, most investigations of plant adaptation to the spaceflight environment have been carried out on the dicotyledonous model plant,... -
Quantifying Cancellous Bone Structural Changes in Microgravity: Axial...
Objective of this study was to further validate bone degradation in microgravity as site-specific and preferential to weight bearing bone. An objective of this study was to... -
Spaceflight-induced (STS-62) vertebral bone loss in ovariectomized rats is...
There is often a reciprocal relationship between bone marrow adipocytes and osteoblasts, suggesting that marrow adipose tissue (MAT) antagonizes osteoblast differentiation. MAT... -
Altered rodent gait characteristics after ~35 days in orbit aboard the...
The long-term adaptations to microgravity and other spaceflight challenges within the confines of a spacecraft, and readaptations to weight-bearing upon reaching a destination,...