Multi-omic investigations of mouse liver subjected to simulated spaceflight freezing and storage protocols

This study compares standard laboratory protocols for tissue freezing and storage with a simulation of the delayed processing of liver specimens and long-term storage protocols used during the Rodent Research-1 (RR-1) payload. Liver samples from twelve-week old female C57/BL6 mice (snap frozen vs. 25 min. slow-frozen and stored for 3 days vs. 1 year) received from the RR-1 project were processed for extraction of RNA DNA and protein. RNA-seq whole genome bisulfite sequencing and mass spectrometry proteomics were performed. These multi-omics datasets will help distinguish the effects of freezing and storage time that could confound the interpretation of the Rodent Research-1 datasets.

Data and Resources

Additional Info

Field Value
Maintainer GeneLab Outreach
Last Updated April 23, 2025, 22:37 (UTC)
Created March 31, 2025, 13:46 (UTC)
accessLevel public
accrualPeriodicity irregular
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harvest_source_title DNG Legacy Data
identifier nasa_genelab_GLDS-49_56j4-37dc
issued 2018-06-26
landingPage https://data.nasa.gov/dataset/multi-omic-investigations-of-mouse-liver-subjected-to-simulated-spaceflight-freezing-and-s
modified 2023-01-26
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