Effect of acute muscle unloading on soleus and gastrocnemius muscle gene expression

Gene expression changes induced by acute skeletal muscle unloading which leads to physiological changes including muscle atrophy fibre-type switching and loss of ability to transition between lipid and glucose as energy source (metabolic inflexibility) was investigated by hind-limb suspension (HLS) treatment of Male ICR mice (28 x9632 g body wt; Harlan Indianapolis IN). Agilent Whole Mouse Genome Oligo Microarrays were utilised to examine the effects of HLS on mRNA expression profiles of the soleus muscle and the gastrocnemius muscle in the hindlimbs of freely ambulating control and 24h HLS treated mice.

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Additional Info

Field Value
Maintainer GeneLab Outreach
Last Updated April 23, 2025, 22:48 (UTC)
Created March 31, 2025, 19:13 (UTC)
accessLevel public
accrualPeriodicity irregular
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harvest_source_title DNG Legacy Data
identifier nasa_genelab_GLDS-227_gdv2-w3kb
issued 2021-05-21
landingPage https://data.nasa.gov/dataset/effect-of-acute-muscle-unloading-on-soleus-and-gastrocnemius-muscle-gene-expression
license http://www.usa.gov/publicdomain/label/1.0/
modified 2023-01-26
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