-
Plasticity of the human IgM repertoire in response to a long-term spaceflight
Immune dysregulation is among the main adverse outcomes of spaceflight. Despite its crucial role in host protection effects on the human antibody repertoire are unknown.... -
Exposure of zebrafish larvae to 3g and 5g hyper gravity between 5-6 days...
The general objective of the study was to determine modulation of gene expression by environmental factors, with a special emphasis on bone formation. For this reason, the... -
Zebrafish larvae submitted to simulated microgravity on a clinostat (CLINO)...
The general objective of the study was to determine modulation of gene expression by environmental factors specifically simulation of microgravity with a special emphasis on... -
Response of the EPI-200 human 3-D skin model to high and low doses of protons
Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different necessitating the direct study of low dose responses. Most... -
Effect of a 91 day long stay in weightlessness on the International Space...
Comparitive gene expression in skin between mice maintained in microgravity (0g) and normogravity (1g) environment. Six male C57Bl/J10 mice were housed for 91 days in the... -
Characterization of Epigenetic Regulation in an Extraterrestrial...
When germinated and grown on-board the ISS (International Space Station) plant do not exhibit abnormal structures but they do have altered growth habits and this project aims to... -
Muscle atrophy osteoporosis prevention in hibernating mammals
Physical inactivity decreases the mechanical load on the skeleton which when prolonged leads to losses of muscle strength and bone mass in humans and most mammalian species.... -
Transcription profiling of Drosophila exposed to a levitation magnet for...
Drosophila samples were exposed to the levitation magnet inside a 25mm diameter tubes with 3 ml of yeast-based Drosophila food in the bottom and a chamber of only 5 mm of height... -
Exposure of zebrafish larvae to relative microgravity between 5-6 days...
The general objective of the study was to determine modulation of gene expression by environmental factors with a special emphasis on bone formation. For this reason the... -
HARV replication of the BRIC-21 Bacillus subtilis spaceflight samples
Previous spaceflight experiments using Bacillus subtilis have reported altered transcriptome profiles during spaceflight compared to matching ground samples. This study tried to... -
RNAseq analysis of the response of Arabidopsis thaliana to fractional...
Traveling to nearby extraterrestrial objects having a reduced gravity level (partial gravity) compared to Earth's gravity is becoming a realistic objective for space agencies.... -
Global DNA methylation profiling of radiation-induced rat mammary carcinomas
To investigate DNA methylation patterns in rat mammary carcinomas induced by ionizing radiation. DNA methylation patterns were analyzed in radiation-induced rat mammary... -
During development the Sku5 mutant roots engage different genes than wild...
The wild type WS plants and the Sku5 mutant plants in the WS background were germinated on ISS or on the ground and the gene expression profiles in roots at 4 days or 8 days... -
Exposure of zebrafish larvae to relative microgravity between 5-6 days...
The general objective of the study was to determine modulation of gene expression by environmental factors with a special emphasis on bone formation. For this reason the... -
Effects of 21 days of bedrest on human skeletal muscle gene expression
The present study concerns the effects of 21 days of sustained recumbence (bedrest) on skeletal muscle gene expression. 14 male subjects participated in normoxic bedrest (NBR)... -
Effect of acute muscle unloading on soleus and gastrocnemius muscle gene expression
Gene expression changes induced by acute skeletal muscle unloading which leads to physiological changes including muscle atrophy fibre-type switching and loss of ability to... -
mRNA expression profile in DLD-1 and MOLT-4 cancer cell lines cultured under...
DLD-1 and MOLT-4 cell lines were cultured in a Rotating cell culture system to simulate microgravity and mRNA expression profile was observed in comparison to Static controls.... -
Dynamic gene expression response to altered gravity in human T cells...
We investigated differentially regulated genes in human Jurkat T lymphocytic cells in 20s and 5min microgravity and in hypergravity and compared expression profiles to identify... -
Global gene expression profiling of radiation-induced rat mammary carcinomas
To investigate gene expression patterns in rat mammary carcinomas induced by ionizing radiation. Gene expression patterns were analyzed in radiation-induced rat mammary... -
Gene expression response to simulated gravity and hypergravity in human T cells
We investigated differentially regulated and stably expressed genes in human Jurkat T lymphocytic cells in 5min simulated microgravity and hypergravity and compared expression...