-
The Role of PTHrP in Osteoblast Response to Microgravity: Implications for...
Prolonged skeletal unloading through bedrest results in bone loss similar to that observed in elderly osteoporotic patients but with an accelerated timeframe. This rapid effect... -
Zebrafish larvae submitted to simulated microgravity on a clinostat (CLINO)...
The general objective of the study was to determine modulation of gene expression by environmental factors specifically simulation of microgravity with a special emphasis on... -
Expression profiling of murine lung 70 days following exposure to...
Irradiation of the K-rasLA1 mouse model with a fractionated dose of 1.0Gy 56Fe- particles increases the incidence of invasive carcinoma compared to unirradiated controls or... -
Effects of bedrest and hypoxia on human skeletal muscle miRNA expression
The present study concerns the effects of 21 days of sustained recumbence (bedrest) and hypoxia alone and in combination on skeletal muscle microRNA expression. 14 male subjects... -
Alteration of Proteomes in First-generation Cultures of Bacillus pumilus...
Bacillus pumilus SAFR-032 was originally isolated from the Jet Propulsion Lab Spacecraft Assembly Facility and thoroughly characterized for its enhanced resistance to UV... -
Effects of a Closed Space Environment on Gene Expression in Hair Follicles...
In recent times long-term stay has become a common occurrence in the International Space Station (ISS). However adaptation to the space environment can sometimes pose... -
Transcription profiling of human peripheral blood to development gene...
To further development of our gene expression approach to biodosimetry we have employed whole genome microarray expression profiling as a discovery platform to identify genes... -
Environmental and facility conditions promote singular gravity responses of...
Genome-wide transcriptional profiling showed that reducing gravity levels in the International Space Station (ISS) causes important alterations in Drosophila gene expression... -
Dynamic nature of epigenetic patterns observed during the Mars 520-d mission...
Interplanetary human spaceflight represents a formidable medical challenge but also provides a unique platform for investigating human adaptation to extreme environmental... -
Effect of microgravity on brain gene expression in mice
Changes in gravitational force such as that experienced by astronauts during space flight induce a redistribution of fluids from the caudad to the cephalad portion of the body... -
Effect of microgravity on HUVECs (Human Umbilical vein Endothelial cells)...
Adaptation of humans in low gravity conditions is a matter of utmost importance when efforts are on to a gigantic leap in human space expeditions for tourism and formation of... -
A study of gene expression influenced by simulated microgravity in human...
Here in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the cultured TK6... -
Expression profiling of soleus muscle under the effect of simulated spaceflight
Spaceflight imposes the risk of skeletal muscle atrophy for astronauts. The understanding of muscle atrophy because of spaceflight is limited but continued efforts are essential... -
['RNA sequencing of zebrafish embryos under simulated microgravity conditions']
['To reveal the potential mechanisms involved in the dysfunction of antiviral immune responses under simulated microgravity conditions, we investigated the transcriptional... -
Comparison of gene expression profiles of normal human bronchial epithelial...
The experiment is part of a project to study DNA repair process after ionizing radiation in organotypic 3-dimentional human bronchial epithlial cell culture. Human bronchial... -
Low dose (0.04 Gy) irradiation (LDR) and hindlimb unloading (HLU)...
The purpose of the present study was to evaluate damage in brain and eye in a ground-based model for spaceflight which includes prolonged unloading and low-dose radiation. Low-... -
Effect of simulated microgravity on E. coli K12 MG1655 growth and gene expression
This study demonstrates simulated microgravity effects on E. coli K 12 MG1655 when grown on LB medium supplemented with glycerol. The results imply that E. coli readily... -
Gene expression in human peripheral blood 48 hours after exposure to...
Analysis of human peripheral blood 48 hours after irradiation ex vivo with graded doses of gamma rays. Results have been used in building and testing classifiers to predict... -
The Heat-Inducible Transcription Factor HsfA2 Enhances Anoxia Tolerance in...
Anoxia induces several heat shock proteins and a heat pre-treatment can acclimatize Arabidopsis seedlings to a subsequent anoxic treatment. In this work we analyzed the response... -
Identifying radiation exposure biomarkers from mouse blood transcriptome
Here we present a whole-genome survey of the murine transcriptomic response to physiologically-relevant radiation doses 2 and 8 Gy. There are 18 distinct biological samples...