['RNA sequencing of zebrafish embryos under simulated microgravity conditions']

['To reveal the potential mechanisms involved in the dysfunction of antiviral immune responses under simulated microgravity conditions, we investigated the transcriptional changes related to the status of innate immune responses by RNA-seq with poly I:C or mock PBS treatment under Normal gravity or simulated microgravity conditions. Our results indicate that the retinoic acid inducible gene (RIG)-I-like receptor (RLR) and Toll-like receptor (TLR) signal pathways, which are both involved in the type-I interferon induction, are significantly inhibited by simulated microgravity effects.']

Data and Resources

Additional Info

Field Value
Maintainer GeneLab Outreach
Last Updated April 23, 2025, 22:36 (UTC)
Created March 31, 2025, 13:11 (UTC)
accessLevel public
accrualPeriodicity irregular
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harvest_source_title DNG Legacy Data
identifier nasa_genelab_GLDS-373_3upt-7jnj
issued 2021-05-21
landingPage https://data.nasa.gov/dataset/rna-sequencing-of-zebrafish-embryos-under-simulated-microgravity-conditions
license http://www.usa.gov/publicdomain/label/1.0/
modified 2023-01-26
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