The Near-Earth Object Wide-field Infrared Survey Explorer Reactivation Mission (NEOWISE; Mainzer et al. 2014, ApJ, 792, 30) is a NASA Planetary Science Division space-based survey to detect, track and characterize asteroids and comets, and to learn more about the population of near-Earth objects that could pose an impact hazard to the Earth. NEOWISE systematically images the sky at 3.4 and 4.6 μm, obtaining multiple independent observations on each location that enable detection of previously known and new solar system small bodies by virtue of the their motion. Because it is an infrared survey, NEOWISE detects asteroid thermal emission and is equally sensitive to high and low albedo objects.\n\nThe Single-exposure Source Database is a compendium of position and flux information for source detections made on the individual NEOWISE 7.7s W1 and W2 Single-exposure images. Because NEOWISE scanned the same region of the sky multiple times, the Single-exposure Database contains multiple, independent measurements of objects. Positions, magnitudes in the two NEOWISE bands, astrometric and photometric uncertainties, flags indicating measurement quality, the time of observations and associations with the AllWISE Source Catalog and 2MASS Point Source Catalog are presented for entries in the Database.