A study of alterations in DNA epigenetic modifications (5mC and 5hmC) influenced by simulated microgravity in human lymphoblastoid cells

Here in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the cultured TK6 lymphoblastoid cells upon exposure to micro-gravity conditions. The results reported here indicate that simulated microgravity alters methylation patterns in a limited way and subsequently the expression of genes involved in stress response like ATF3 FBXO17 MAP3K13 and VCL in TK6 cells. Overall design: Examination of RNA-seq with 2 replicates each for 1 cell type

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Additional Info

Field Value
Maintainer GeneLab Outreach
Last Updated April 23, 2025, 22:50 (UTC)
Created March 31, 2025, 19:40 (UTC)
accessLevel public
accrualPeriodicity irregular
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harvest_source_id 61638e72-b36c-4866-9d28-551a3062f158
harvest_source_title DNG Legacy Data
identifier nasa_genelab_GLDS-86_hdmh-sact
issued 2018-06-26
landingPage https://data.nasa.gov/dataset/a-study-of-alterations-in-dna-epigenetic-modifications-5mc-and-5hmc-influenced-by-simulate
modified 2023-01-26
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publisher National Aeronautics and Space Administration
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