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Rodent Research-1 (RR1) NASA Validation Flight: Mouse liver transcriptomic...
RR-1 is a validation flight to evaluate the hardware operational and science capabilities of the Rodent Research Project on the ISS. RNA DNA and protein were purified from liver... -
Microbial Observatory (ISS-MO): Molecular characterization of Bacillus...
As part of an ongoing effort to catalogue microbial communities inhabiting the International Space Station (ISS) crew-associated environmental samples were collected from the... -
Expression data from rice calli cultured with 2,4-D
Four days old rice calli were selected to grow 324h under spaceflight controls 1g-flight controls and 1g-ground controls. We used microarrays to detail the global programme of... -
The influence of simulated microgravity on the proteome of Daphnia magna
Background/Objectives: The waterflea Daphnia is an interesting candidate for bioregenerative life support systems (BLSS). These animals are particularly promising because of... -
Spaceflight effects on the mouse retina: Histological gene expression and...
We report the findings of an animal experiment onboard STS-135 investigating the molecular aspects of the impact of spaceflight on retinal biology by performing differential... -
Transcriptomic analysis of spleens from mice subjected to chronic low-dose...
The purpose of this study was to evaluate transcriptional changes in mouse spleens using a ground-based model for spaceflight. This model includes prolonged unloading and low-... -
Biological Research in Canisters-16 (BRIC-16): Investigations of the plant...
These investigations studied the fundamentals of how plants perceive gravity and develop in microgravity. It informs how gene regulation is altered by spaceflight conditions. -
Transcriptomic analysis of liver from mice subjected to simulated...
To understand the molecular mechanisms affected by spaceflight it is essential to achieve high quality sample preservation on-orbit for downstream gene expression analysis.... -
Eruca sativa Rocket Science RNA-seq
In the Rocket Science citizen science project Eruca sativa (salad rocket) seeds stored for six months on board of the International Space Station caused delayed crop... -
Synergistic effects of microgravity and space radiation (Nimblegen)
Space radiations and microgravity both could cause DNA damage in cells but the effects of microgravity on DNA damage response to space radiations are still controversial. A mRNA... -
Spatially resolved transcriptional analysis of hearts from mice flown on the...
The Rodent Research-3 (RR-3) mission was sponsored by the pharmaceutical company Eli Lilly and Co. and the Center for the Advancement of Science in Space to study the... -
Low dose (0.04 Gy) irradiation (LDR) and hindlimb unloading (HLU)...
The purpose of the present study was to evaluate damage in brain and eye in a ground-based model for spaceflight which includes prolonged unloading and low-dose radiation. Low-... -
RAD51 Interconnects Between DNA Replication DNA Repair and Immunity
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a... -
Effects of 21 days of bedrest on human skeletal muscle gene expression
The present study concerns the effects of 21 days of sustained recumbence (bedrest) on skeletal muscle gene expression. 14 male subjects participated in normoxic bedrest (NBR)... -
Streptococcus mutans differential gene expression in response to simulated...
Astronauts have been previously shown to exhibit decreased salivary lysozyme and increased dental calculus and gingival inflammation in response to space flight host factors... -
Kineosporiaceae bacterium B12 whole genome shotgun sequencing project
Rubinsicoccus jplei genome a novel genus isolated from JPL spacecraft environment where Mars 2020 subsystems are assembled. -
Impact of spaceflight on gene expression in the thymus
The thymus undergoes atrophy during spaceflight. In this study we analyzed gene expression of the thymus of mice on board International space station to elucidate molecular... -
Proton irradiation augments the reduction in tumor progression observed with...
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have shown that in... -
RNA-Seq transcriptome analysis of reactive oxygen species gene network in...
Space environment is suspected to generate reactive oxygen species (ROS) and induce oxidative stress in plants however little is known about the gene expression of ROS gene... -
The influence of simulated microgravity on the proteome of Daphnia magna
Background/Objectives: The waterflea Daphnia is an interesting candidate for bioregenerative life support systems (BLSS). These animals are particularly promising because of...