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Microgravity effect on C. elegans N2/VC (CERISE 4 days)
Microgravity effect on C. elegans gene expression was analysed by whole genome microarray. The worms were cultivated under microgravity for 4 days in the Japanese Module of the... -
Gene-expression profiling of Saccharomyces cerevisiae irradiated by high-LET...
Ionizing radiations are categorized by linear energy transfer (LET) into low-LET and high-LET. High-LET is considered to have a higher relative biological effectiveness (RBE)... -
Response of the EPI-200 human 3-D skin model to high and low doses of protons
Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different necessitating the direct study of low dose responses. Most... -
Hindlimb suspension and reloading study
Analysis of effect of hindlimb suspension and reloading on C57Bl/6 mouse soleus muscle. Experimental groups examined: -Control mice 14 days -Hindlimb suspension for 7 days... -
mRNA expression profile in DLD-1 and MOLT-4 cancer cell lines cultured under...
DLD-1 and MOLT-4 cell lines were cultured in a rotating cell culture system to simulate microgravity and mRNA expression profile in comparison to Static controls. Cells were... -
RAD51 Interconnects Between DNA Replication DNA Repair and Immunity
RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a... -
Synergistic effects of microgravity and space radiation (Nimblegen)
Space radiations and microgravity both could cause DNA damage in cells but the effects of microgravity on DNA damage response to space radiations are still controversial. A mRNA... -
Synergistic effects of space radiation and microgravity (miRNA WT and dys-mutant)
Space radiations and microgravity both could cause DNA damage in cells but the effects of microgravity on DNA damage response to space radiations are still controversial. A mRNA... -
Dynamic gene expression response to altered gravity in human myelomonocytic...
We investigated differentially regulated genes in human myelomonocytic U937 cells in 20s and 5min microgravity and in hypergravity and compared expression profiles to identify... -
Global gene expression analysis highlights microgravity sensitive key genes...
Microgravity exposure as well as chronic muscle disuse are two of the main causes of physiological adaptive skeletal muscle atrophy in humans and murine animals in physiological... -
Synergistic effects of space radiation and microgravity (miRNA WT and ced-1 mutant)
Space radiations and microgravity both could cause DNA damage in cells but the effects of microgravity on DNA damage response to space radiations are still controversial. A mRNA... -
Global DNA methylation profiling of radiation-induced rat mammary carcinomas
To investigate DNA methylation patterns in rat mammary carcinomas induced by ionizing radiation. DNA methylation patterns were analyzed in radiation-induced rat mammary... -
Global gene expression analysis highlights microgravity sensitive key genes...
Microgravity as well as chronic muscle disuse are two causes of low back pain originated at least in part from paraspinal muscle deconditioning. At present no study investigated... -
Identification of miRNAs involved in cell response to ionising radiation and...
BACKGROUND: Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis initiation.... -
Effect of acute muscle unloading on soleus and gastrocnemius muscle gene expression
Gene expression changes induced by acute skeletal muscle unloading which leads to physiological changes including muscle atrophy fibre-type switching and loss of ability to... -
Global gene expression profiling of radiation-induced rat mammary carcinomas
To investigate gene expression patterns in rat mammary carcinomas induced by ionizing radiation. Gene expression patterns were analyzed in radiation-induced rat mammary... -
Dynamic gene expression response to altered gravity in human myelomonocytic...
We investigated differentially regulated genes in human myelomonocytic U937 cells in 20s and 5min microgravity and in hypergravity and compared expression profiles to identify... -
Comparative gene expression analysis in the Arabidopsis thaliana root apex...
The root apex is an important section of the plant root involved in environmental sensing and cellular development. Analyzing the gene profile of root apex in diverse... -
Expression Data from International C. elegans Experiment 1st (ICE-FIRST)
The effect of microgravity on gene expression in C.elegans was comprehensively analysed by DNA microarray (Agilent). Overall design: Mix staged C. elegans N2 was exposed... -
Galactic cosmic radiation induces stable epigenome alterations relevant to...
Human deep space and planetary travel is limited by uncertainties regarding the health risks associated with exposure to galactic cosmic radiation (GCR) and in particular the...