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Spaceflight effects on the mouse retina: Histological gene expression and...
We report the findings of an animal experiment onboard STS-135 investigating the molecular aspects of the impact of spaceflight on retinal biology by performing differential... -
Biological Research in Canisters-16 (BRIC-16): Investigations of the plant...
These investigations studied the fundamentals of how plants perceive gravity and develop in microgravity. It informs how gene regulation is altered by spaceflight conditions. -
Gene-expression profiling of Saccharomyces cerevisiae irradiated by high-LET...
Ionizing radiations are categorized by linear energy transfer (LET) into low-LET and high-LET. High-LET is considered to have a higher relative biological effectiveness (RBE)... -
Microarray Analysis of Space-flown Murine Thymus Tissue
Microarray Analysis of Space-flown Murine Thymus Tissue Reveals Changes in Gene Expression Regulating Stress and Glucocorticoid Receptors. We used microarrays to detail the gene... -
Response of the EPI-200 human 3-D skin model to high and low doses of protons
Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different necessitating the direct study of low dose responses. Most... -
mRNA expression profile in DLD-1 and MOLT-4 cancer cell lines cultured under...
DLD-1 and MOLT-4 cell lines were cultured in a rotating cell culture system to simulate microgravity and mRNA expression profile in comparison to Static controls. Cells were... -
A whole-genome microarray study of Arabidopsis thaliana cell cultures...
Arabidopsis thaliana wild type cell cultures were exposed to a 5-day space flight onboard of Shenzhou 8 to identify microgravity and space effect related gene expression. -
Transcription profiling of Arabidopsis seedings exposed to UV-B irradiation
Interaction of COP1 and UVR8 which regulate UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis thaliana. -
Global gene expression analysis highlights microgravity sensitive key genes...
Microgravity exposure as well as chronic muscle disuse are two of the main causes of physiological adaptive skeletal muscle atrophy in humans and murine animals in physiological... -
Global gene expression analysis highlights microgravity sensitive key genes...
Microgravity as well as chronic muscle disuse are two causes of low back pain originated at least in part from paraspinal muscle deconditioning. At present no study investigated... -
Gene expression profiling in human fibroblast after low-LET irradiation
Exposure to radiation provokes cellular responses controlled in part by gene expression networks. MicroRNAs (miRNAs) are small non-coding RNAs which mostly regulate gene... -
Effect of acute muscle unloading on soleus and gastrocnemius muscle gene expression
Gene expression changes induced by acute skeletal muscle unloading which leads to physiological changes including muscle atrophy fibre-type switching and loss of ability to... -
Dynamic gene expression response to altered gravity in human T cells...
We investigated differentially regulated genes in human Jurkat T lymphocytic cells in 20s and 5min microgravity and in hypergravity and compared expression profiles to identify... -
Global gene expression profiling of radiation-induced rat mammary carcinomas
To investigate gene expression patterns in rat mammary carcinomas induced by ionizing radiation. Gene expression patterns were analyzed in radiation-induced rat mammary... -
Comparative gene expression analysis in the Arabidopsis thaliana root apex...
The root apex is an important section of the plant root involved in environmental sensing and cellular development. Analyzing the gene profile of root apex in diverse... -
Environmental and facility conditions promote singular gravity responses of...
Genome-wide transcriptional profiling showed that reducing gravity levels in the International Space Station (ISS) causes important alterations in Drosophila gene expression... -
Expression profiling of soleus muscle under the effect of simulated spaceflight
Spaceflight imposes the risk of skeletal muscle atrophy for astronauts. The understanding of muscle atrophy because of spaceflight is limited but continued efforts are essential... -
Low dose (0.04 Gy) irradiation (LDR) and hindlimb unloading (HLU)...
The purpose of the present study was to evaluate damage in brain and eye in a ground-based model for spaceflight which includes prolonged unloading and low-dose radiation. Low-...